A method for patient-specific absorbed dose estimation for internal beta emitters

Citation
Le. Williams et al., A method for patient-specific absorbed dose estimation for internal beta emitters, CLIN CANC R, 5(10), 1999, pp. 3015S-3019S
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
5
Issue
10
Year of publication
1999
Supplement
S
Pages
3015S - 3019S
Database
ISI
SICI code
1078-0432(199910)5:10<3015S:AMFPAD>2.0.ZU;2-4
Abstract
The purpose of the study was to determine a technique for estimating patien t-specific absorbed radiation doses in radioimmunotherapy and other interna l emitter therapies. beta Radiation sources were considered, with Y-90 bein g the radionuclide of primary interest. Organ uptake of activity was determ ined using a merged set of computed tomography and planar nuclear images. E stimation of local absorbed dose was accomplished using a voxel source kern el. Voxel size was 0.2 x 0.2 x 0.5 cm; dimensions were from the digital res olution of the nuclear and computed tomography data sets. Dose-volume histo grams were also obtained due to the voxel nature of the estimations. Organ dose estimates were made for two patients receiving the chimeric anticarcin oembryonic antigen antibody cT84.66. Considerable variation was observed wh en comparing the voxel kernel results with medical internal radiation dosim etry values obtained via the MIRDOSE3 program. Primary uncertainty in the o rgan dose estimates was determined to be due to the variation in organ mass . By correcting the S values in that program by the organ mass ratio, we fo und generally good agreement between our method and MIRDOSE3. We conclude t hat patient-specific absorbed doses can be estimated for Y-90-labeled antib odies.