Dual-phase response model for bronchial asthma

Citation
Y. Tohda et al., Dual-phase response model for bronchial asthma, ALL ASTH P, 21(2), 2000, pp. 79-84
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
ALLERGY AND ASTHMA PROCEEDINGS
ISSN journal
1088-5412 → ACNP
Volume
21
Issue
2
Year of publication
2000
Pages
79 - 84
Database
ISI
SICI code
1088-5412(200003/04)21:2<79:DRMFBA>2.0.ZU;2-8
Abstract
The authors have successfully developed an animal model of dual-phase bronc hial responses and very high IgG titer by sensitizing Hartley-strain male g uinea pigs. Specific airway resistance, which was determined in a two-chamb er body plethysmograph, was elevated to sevenfold during immediate response , followed by a late phase response with a smaller but marked elevation in resistance. Furthermore, hematological and histological examinations reveal ed that the total cell count increased in BAL obtained during both immediat e and late bronchial responses as compared to pre-OVA challenges. A,signifi cant increase in BAL eosinophils was present only for the late bronchial sa mples, and this finding was supported by histological examination.