A novel, metal-free oxidation system for the catalytic synthesis of aldehyd
es and ketones-TEMPO/Oxone-has been developed. An optimized reaction protoc
ol proved especially successful for the synthesis of ketones. Additionally,
the influence of quarternary ammonium salts on the catalysis was studied.
The mild conditions of this novel procedure were shown to tolerate even sen
sitive silyl protective groups which can otherwise be cleaved in the presen
ce of Oxone.