Catalytic synthesis of aldehydes and ketones under mild conditions using TEMPO/Oxone

Citation
C. Bolm et al., Catalytic synthesis of aldehydes and ketones under mild conditions using TEMPO/Oxone, ORG LETT, 2(8), 2000, pp. 1173-1175
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
2
Issue
8
Year of publication
2000
Pages
1173 - 1175
Database
ISI
SICI code
1523-7060(20000420)2:8<1173:CSOAAK>2.0.ZU;2-Y
Abstract
A novel, metal-free oxidation system for the catalytic synthesis of aldehyd es and ketones-TEMPO/Oxone-has been developed. An optimized reaction protoc ol proved especially successful for the synthesis of ketones. Additionally, the influence of quarternary ammonium salts on the catalysis was studied. The mild conditions of this novel procedure were shown to tolerate even sen sitive silyl protective groups which can otherwise be cleaved in the presen ce of Oxone.