New 4',5',2,3.4-substituted 2'-amino chalcones were synthesized and evaluat
ed for cytotoxicity against a panel of human tumor cell lines. Several comp
ounds displayed significant cytotoxicity. The most promising lead molecule
(10) also had high activity toward multi-drug resistant KB-VIN, and ovarian
1A9 cell lines. 2'-Amino chalcones demonstrated significantly increased an
titumor activity compared with the corresponding chalcones, while, the epox
ide derivatives generally showed greatly reduced activity. (C) 2000 Elsevie
r Science Ltd. All rights reserved.