Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia

Citation
Rl. Zimmerman et al., Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia, ARCH PATH L, 124(4), 2000, pp. 625-627
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
ISSN journal
0003-9985 → ACNP
Volume
124
Issue
4
Year of publication
2000
Pages
625 - 627
Database
ISI
SICI code
0003-9985(200004)124:4<625:CAIA5M>2.0.ZU;2-O
Abstract
Finasteride has been associated with the development of gynecomastia. Altho ugh cytoplasmic vacuolization has been noted in prostatic epithelium in men taking this drug, we found no documentation of the cytologic changes in fi nasteride-associated gynecomastia. We present the case of a 53-year-old man who developed unilateral gynecomastia following finasteride therapy for al opecia. A fine-needle aspiration biopsy of the mass was diagnosed as adenoc arcinoma on the basis of nuclear atypia and particularly because of cytopla smic vacuolization. Subsequent excisional biopsy revealed benign gynecomast ia with no evidence of malignant change. The ductal epithelium did exhibit cytoplasmic vacuolization similar to that described in the prostate followi ng finasteride therapy. We believe this is the first reported case document ing the cytologic changes seen in gynecomastia secondary to finasteride the rapy. Cytoplasmic vacuolization in this setting should not be considered ev idence of malignancy in men with gynecomastia. As with gynecomastia in gene ral, extreme caution should be used before rendering a cytologic diagnosis of malignancy.