Effect of brief maximal exercise on circulating levels of interleukin-12

Citation
T. Akimoto et al., Effect of brief maximal exercise on circulating levels of interleukin-12, EUR J A PHY, 81(6), 2000, pp. 510-512
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
ISSN journal
1439-6319 → ACNP
Volume
81
Issue
6
Year of publication
2000
Pages
510 - 512
Database
ISI
SICI code
1439-6319(200004)81:6<510:EOBMEO>2.0.ZU;2-K
Abstract
Interleukin-12 (IL-12) is a cytokine that was originally identified as natu ral killer cell stimulatory factor. It induces the activity of T-helper 1 ( Th1) cells and exhibits strong anti-tumor activity. In this study, we studi ed the effects of brief anaerobic maximal exercise on circulating levels of IL-12. Six healthy males [mean (SD) 25.2 (2.6) years] performed a modified Wingate test exercise (resistance 0.075 kg/kg of body mass). The exercise consisted of five bouts of maximal cycling for 10 s, with rest intervals of 50 s between them. Blood samples were taken before, immediately after, 30 min after, 60 min after and 120 min after the exercise. Plasma concentratio ns of IL-12 were measured using an enzyme-linked immunosorbent assay. Data were corrected for hemoglobin and hematocrit measurements. Plasma concentra tions of IL-12 averaged [mean (SD)] 234.2 (40.9) pg/ml before, 305.2 (62.1) pg/ml immediately after, 202.8 (24.2) pg/ml 30 min after, 239.7 (35.1) pg/ ml 60 min after, and 199.6 (49.2) pg/ml 120 min after the exercise. We show ed that plasma concentrations of IL-12 increased significantly immediately after brief anaerobic maximal cycle ergometer exercise (P < 0.01).