Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients

Citation
Ad. Monforte et al., Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients, AIDS, 14(5), 2000, pp. 499-507
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AIDS
ISSN journal
0269-9370 → ACNP
Volume
14
Issue
5
Year of publication
2000
Pages
499 - 507
Database
ISI
SICI code
0269-9370(20000331)14:5<499:IITRFD>2.0.ZU;2-3
Abstract
Objective: To evaluate the frequency of discontinuation of the first highly active antiretroviral regimen (HAART) and the factors predictive of discon tinuing for toxicity and failure in a population-based cohort of HIV-positi ve individuals in Italy, naive from antiretrovirals at enrolment. Methods: The study population consisted of individuals who initiated HAART and had at least one follow-up visit. The primary end-points were discontin uation of any component of HAART for drug toxicity and discontinuation for failure. Survival analyses were performed to identify predictive factors fo r reaching the two end points. Results: Eight hundred and sixty-two individuals initialed HAART; in 727 of them (84.3%) this consisted of two nucleoside reverse transcriptase inhibi tors (NRTI) and one protease inhibitor (PI). Over a median follow-up of 45 weeks, 312 patients (36.2%) discontinued therapy: 182 (21.1%) discontinued due to toxicity, 44 (5.1%) due to failure. The probability of discontinuing HAART at 1 year was 25.5% [95% confidence interval (Cl), 21.9-28.9] due to toxicity and 7.6% (95% Cl, 4.9-10.3) due to failure. Independent factors a ssociated with discontinuation for toxicity were: gender [relative hazard ( RH) = 0.51; 95% Cl, 0.32-0.80 for men versus women], type of treatment (ind inavir-containing regimens, RH = 1.94; 95% Cl, 1.10-3.41 and ritonavir-cont aining regimens, RH = 3.83; 95% Cl, 2.09-7.03 versus hard-gell saquinavir) and time spent on treatment (RH = 0.89; 95% Cl, 0.80-0.98 for each addition al month). Discontinuation due to failure was independently associated with the most recent HIV-RNA (RH = 3.20; 959/0 Cl, 1.74-5.88 for log(10) copies /ml higher), and with type of treatment (indinavir-containing regimens, RH = 0.21; 95% Cl, 0.06-0.78 and ritonavir-containing regimens, RH = 0.23; 95% Cl, 0.04-1.26 Versus hard-gell saquinavir). Conclusions: If the current HAART regimen caused no toxicity, less than 10% of naive patients discontinue their first HAART regimen because of failure after 1 year from starting therapy. (C) 2000 Lippincatt Williams & Wilkins .