GC/MS and GC/MS-MS systems utilisation for the analytical diagnosis in clinical toxicology

Citation
G. Cretu et al., GC/MS and GC/MS-MS systems utilisation for the analytical diagnosis in clinical toxicology, REV CHIM, 50(12), 1999, pp. 839-846
Citations number
16
Language
RUMENO
art.tipo
Article
Categorie Soggetti
Chemical Engineering
Journal title
REVISTA DE CHIMIE
ISSN journal
0034-7752 → ACNP
Volume
50
Issue
12
Year of publication
1999
Pages
839 - 846
Database
ISI
SICI code
0034-7752(199912)50:12<839:GAGSUF>2.0.ZU;2-#
Abstract
The authors presented two cases: the analysis of black market product, used by an admitted patient, by using GC-MS technique rind the analysis of a ur ine sample for an multiple acute poisoning case with amorbital and diazepam , by using GC-MS/MS technique; they also presented the sample preparation m ethod The obtained data (chromatograms and mass spectral show that the GC-M S method is very useful for certitude diagnosis both for diverse products a nd drugs, used by patients and the GC-MS/MS technique significantly increas e the signal-to-noise ratio. GC-MS method is one of the best screening meth od used in Clinical Toxicology Laboratories and GC/MS/MS technique is very sensitive method for the determination of some unknown chemical structures.