Transtentorial cerebellar c-jun expression after focal cerebral cortical injury in mice

Citation
Js. Liu et al., Transtentorial cerebellar c-jun expression after focal cerebral cortical injury in mice, NEUROSCI L, 282(1-2), 2000, pp. 85-88
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
282
Issue
1-2
Year of publication
2000
Pages
85 - 88
Database
ISI
SICI code
0304-3940(20000317)282:1-2<85:TCCEAF>2.0.ZU;2-5
Abstract
Delayed and remote effect of focal cerebral cortical lesion on cerebellum r emains unclear. The c-Jun, an inducible transcription factor of cellular im mediate early gene, is the predominant transcription factor and consistent marker for neurons that respond to stress or injury. We use a mouse cryogen ic injury model to study the spatial and temporal changes of c-jun in the c erebellum after focal neocortical lesion. A transient and moderate expressi on of c-jun mRNA was found in the cerebellum with central dominance since 3 day postinjury a nd gradually subsided with in 2 weeks. A distinct increme nt of c-Jun protein expression in Purkinje cells of the bilateral cerebella r hemispheres with focal connotation in the vermis was detected since 1 wee k postinjury. These findings suggest that the delayed and remote c-jun expr ession of the cerebellum, functionally connected with the cerebral cortex, indicate transneuronal gene activation. (C) 2000 Elsevier Science Ireland L td. All rights reserved.