Inhibition of adjuvant-induced inflammatory hyperalgesia in rats by local injection of neurotrophin-3

Citation
M. Watanabe et al., Inhibition of adjuvant-induced inflammatory hyperalgesia in rats by local injection of neurotrophin-3, NEUROSCI L, 282(1-2), 2000, pp. 61-64
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
282
Issue
1-2
Year of publication
2000
Pages
61 - 64
Database
ISI
SICI code
0304-3940(20000317)282:1-2<61:IOAIHI>2.0.ZU;2-1
Abstract
The induction of nerve growth factor(NGF) in inflammatory tissue has been s hown to be involved in hyperalgesia. In the present study, the role of neur otrophin-3 (NT-3) in the regulation of inflammatory hyperalgesia was analyz ed. Inflammatory hyperalgesia was induced by intraplantar injection of comp lete Freund's adjuvant (CFA) to the rat hind paw. NT-3 levels in the planta r skin were much higher than NGF levels (1.24 and 0.14 ng/g tissue, respect ively) before CFA injection, but decreased significantly 6 h to 48 h after the injection while NGF was markedly induced at 6 h but decreased thereafte r. When 1 mu g of NT-3 was locally injected at 5 h after CFA injection at t he time NT-3 levels decreased, hyperalgesia was reversed transiently but sp ecifically. These results suggest an inhibitory role of NT-3 in the regulat ion of pain sensitivity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.