Primary lymphoepithelioma-like carcinoma of the lung

Citation
A. Barroso et al., Primary lymphoepithelioma-like carcinoma of the lung, LUNG CANC, 28(1), 2000, pp. 69-74
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
LUNG CANCER
ISSN journal
0169-5002 → ACNP
Volume
28
Issue
1
Year of publication
2000
Pages
69 - 74
Database
ISI
SICI code
0169-5002(200004)28:1<69:PLCOTL>2.0.ZU;2-R
Abstract
Lymphoepithelioma is an undifferentiated carcinoma with prominent lymphoid stroma in the nasopharynx. Tumors with similar histology have been reported with other localizations, including the lungs, and are designated as lymph oepithelioma-like carcinomas (LELC). Primary LELC of the lung is very rare, and scant information is available in the scientific literature. This pape r details the case of a 25-year-old Caucasian male patient with the diagnos is (determined by thoracotomy) of primary LELC of the lung. Immunohistochem ical analysis was negative for Epstein-Barr virus, as was the in situ hybri dization of the tumor cells. Observation of the nasopharynx and a magnetic resonance image of the cavum were normal. Because the tumor (T4N2M0) could not be resected, the patient was treated with chemotherapy, carboplatin/5-f luorouracil, completing two cycles. The patient's condition worsened when h e developed contralateral pneumonia, which was then followed by pericardial effusion. The patient died 36 h later from cardiac tamponade. Presented he re is a revision of this rare pathology, not often reported in the literatu re. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved .