D. Gerashchenko et al., Strong rebound of wakefulness follows prostaglandin D-2- or adenosine A(2a) receptor agonist-induced sleep, J SLEEP RES, 9(1), 2000, pp. 81-87
We studied the effect of sleep excess on the sleep-wakefulness pattern of r
ats. Subarachnoid infusion of prostaglandin D-2 or the adenosine A(2a) rece
ptor agonist CGS21680 effectively induced slow wave sleep (SWS) for the fir
st 12 h of the night-time period, whereas they did not induce sleep during
the following 24 h of infusion. An increase in the amount of wakefulness wa
s seen during the last 12 h of prostaglandin D-2 infusion. The amounts of w
akefulness strongly increased during the following 36-h recovery period. Re
bound wakefulness was extraordinarily strong after the cessation of CGS2168
0 infusion, reaching almost complete insomnia during the night-time. Treatm
ent of animals with prostaglandin D-2 overnight, following by treatment wit
h CGS21680 on the next night, resulted in the strongest induction of wakefu
lness rebound. During the rebound period, the amount of wakefulness reached
up to 50 min per hour in the daytime. Rebound of wakefulness depended on t
he amounts of preceding SWS induced by infusion of prostaglandin D-2 for 6
or 12 h and of CGS21680 for 12 h. The larger the amount of SWS, the larger
the amount of the following rebound of wakefulness. Rebounds of wakefulness
occurred as a result of decrease in SWS amounts, whereas paradoxical sleep
amounts did not change. Desensitization of adenosine A(2a) receptors and a
ccumulation of prostaglandin E-2 may be involved in the production of stron
g wakefulness rebound following relatively long treatments (more than 12 h)
with prostaglandin D-2 or CGS21680.