The analysis of basic and acidic compounds using non-aqueous CE and non-aqueous CE-MS

Citation
J. Senior et al., The analysis of basic and acidic compounds using non-aqueous CE and non-aqueous CE-MS, J PHARM B, 22(3), 2000, pp. 413-421
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
0731-7085 → ACNP
Volume
22
Issue
3
Year of publication
2000
Pages
413 - 421
Database
ISI
SICI code
0731-7085(200004)22:3<413:TAOBAA>2.0.ZU;2-J
Abstract
It has been shown that non-aqueous capillary electrophoresis (NACE) can pro vide improved separations in comparison to those obtained using conventiona l CE under aqueous conditions [1] (ACE). Previous work carried out in our l aboratories involving initial investigations into the technique have been r eported [2]. Based on the findings of that work it was possible to separate a variety of basic pharmaceuticals from selected impurities and to obtain the successful separation of some hydrophobic sulphonic acids. The successf ul coupling of NACE to mass spectrometry (NACE-MS) has also been demonstrat ed. (C) 2000 Elsevier Science B.V. All rights reserved.