Synthesis of optically pure bisphosphine oxides and related compounds

Citation
M. Sugiya et H. Nohira, Synthesis of optically pure bisphosphine oxides and related compounds, B CHEM S J, 73(3), 2000, pp. 705-712
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
ISSN journal
0009-2673 → ACNP
Volume
73
Issue
3
Year of publication
2000
Pages
705 - 712
Database
ISI
SICI code
0009-2673(200003)73:3<705:SOOPBO>2.0.ZU;2-3
Abstract
Optically pure bisphosphine oxides were conveniently synthesized by Kolbe e lectrolytic coupling reaction of carboxylic acids possessing a chiral phosp hinoyl group in 60-65% isolated yield. This synthetic approach provides a v ariety of accesses to P-chiral bisphosphine ligands. Their absolute configu rations were intercorrelated with that of the previous reported BisP*-boran e. Asymmetric hydrogenation of alpha-(acylamino)acrylic acids by a rhodium complex with BisP* (R = t-octyl or 1,1,3,3-tetramethylbutyl) affords N-acyl amino acids in 94-96% ee.