Pairing SOX off with partners in the regulation of embryonic development

Citation
Y. Kamachi et al., Pairing SOX off with partners in the regulation of embryonic development, TRENDS GEN, 16(4), 2000, pp. 182-187
Citations number
32
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
0168-9525 → ACNP
Volume
16
Issue
4
Year of publication
2000
Pages
182 - 187
Database
ISI
SICI code
0168-9525(200004)16:4<182:PSOWPI>2.0.ZU;2-Y
Abstract
The SOX family of high-mobility group (HMG) domain proteins has recently be en recognized as a key player in the regulation of embryonic development an d in the determination of the cell fate. In the case of certain SOX protein s, they regulate the target genes by being paired off with specific partner factors. This partnering: might allow SOX proteins to act in a cell-specif ic manner, which is key to their role in cell differentiation. The focus of this article is the mechanism of action of SOX proteins, in particular, ho w SOX proteins specifically pair off with respective partner factors and, a s a consequence, select distinct sets of genes as their regulatory targets.