Hemostatic abnormalities in patients with thrombotic complications on maintenance hemodialysis

Citation
A. Inoue et al., Hemostatic abnormalities in patients with thrombotic complications on maintenance hemodialysis, CL APPL T-H, 6(2), 2000, pp. 100-103
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
ISSN journal
1076-0296 → ACNP
Volume
6
Issue
2
Year of publication
2000
Pages
100 - 103
Database
ISI
SICI code
1076-0296(200004)6:2<100:HAIPWT>2.0.ZU;2-M
Abstract
Before hemodialysis (HD), plasma levels of tissue factor (TF), free-TF path way inhibitor (TFPI) and thrombomodulin (TM) were significantly higher in p atients with HD than in healthy volunteers. Plasma levels of (T-F) TFPI and plasmin plasmin inhibitor complex (PPIC) were significantly higher in pati ents with HD than in healthy volunteers. During HD, plasma levels of TF and (T-F) TFPI were not significantly increased, but plasma levels of total TF PI and free TFPI at 1 hour after and at the end of HD were significantly in creased, compared with levels before start of HD. Plasma level of PPIC 1 ho ur after start of HD was significantly higher than before start of HD, and plasma levels of thrombin antithrombin complex (TAT), PPIC, D-dimer, TM, an d protein C (PC) at the end of HD were significantly higher than before sta rt of HD. In patients with thrombosis complications, plasma TF levels were significantly higher than in patients without thrombotic complications duri ng HD. Plasma levels of PC were significantly lower in patients with thromb otic complications than in patients without thrombotic complications. There was no significant difference between both groups during HD in hemostatic parameters, with the exception of TF and PC. Hemostatic abnormalities existed in patients with HD; especially, increased TF and decreased PC might cause thrombotic complications.