Long-lasting behavioral alterations following a hypoxic/ischemic brain injury in neonatal rats

Citation
W. Balduini et al., Long-lasting behavioral alterations following a hypoxic/ischemic brain injury in neonatal rats, BRAIN RES, 859(2), 2000, pp. 318-325
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
859
Issue
2
Year of publication
2000
Pages
318 - 325
Database
ISI
SICI code
0006-8993(20000324)859:2<318:LBAFAH>2.0.ZU;2-U
Abstract
The characterization of motor and cognitive dysfunctions following a neonat al ischemic injury is a prerequisite to investigate putative pharmacologica l interventions. To this end, in the present study, we evaluated the long-l asting behavioral alterations occurring after a hypoxic/ischemic injury obt ained by the combination of monolateral carotid ligation and exposure to 8% oxygen for 3 h in 7-day-old rats. These animals show a different degree of damage in the side ipsilateral to the occluded artery. Motor coordination, tested both before and after weaning, was not affected, whereas spontaneou s activity was increased at weaning but not in the adult age. When tested i n an open field after apomorphine administration, most ischemic animals sho wed a marked turning behavior ipsilateral to the lesioned side. They also h ad a reduced rate of spontaneous alternation and a marked tendency to visit the arm of the T-maze ipsilateral to the lesion. Injured rats were deficie nt in performing water maze and T-maze acquisition tests but, when evaluate d in a passive avoidance paradigm, no difference from controls was observed . These data indicate that an ischemic insult in neonatal rats causes long- lasting learning deficits and motor behavior asymmetry. These behavioral al terations may represent a useful endpoint for studying the efficacy of pote ntial pharmacological treatments that may improve the behavioral consequenc es of a perinatal hypoxic/ischemic insult in humans. (C) 2000 Elsevier Scie nce B.V. All rights reserved.