Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease

Citation
Rj. Porter et al., Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease, AM J PSYCHI, 157(4), 2000, pp. 638-640
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
AMERICAN JOURNAL OF PSYCHIATRY
ISSN journal
0002-953X → ACNP
Volume
157
Issue
4
Year of publication
2000
Pages
638 - 640
Database
ISI
SICI code
0002-953X(200004)157:4<638:CDIBAT>2.0.ZU;2-D
Abstract
Objective: The study assessed the effects on global cognitive function and mood of a reduction of brain serotonin by means of acute tryptophan depleti on in 16 patients with dementia of the Alzheimer type and in 16 cognitively intact comparison subjects. Method: In a double-blind, crossover design, s ubjects received a tryptophan-free amino acid drink to induce acute tryptop han depletion and, on a separate occasion, a placebo drink containing a bal anced mixture of amino acids. On each occasion, ratings of depressed mood w ere made at baseline and 4 and 7 hours later, and the Modified Mini-Mental State was administered at baseline and 4 hours later. Results: Patients wit h dementia of the Alzheimer type had a significantly lower mean score on th e Modified Mini-Mental State after acute tryptophan depletion than after re ceiving placebo. The comparison group showed no difference in mean score on the Modified Mini-Mental State after acute tryptophan depletion and after receiving placebo. No significant changes in mood were found in either grou p. Conclusions: Acute tryptophan depletion significantly impaired cognitive function in patients with dementia of the Alzheimer type. Compromised sero tonergic function, in combination with cholinergic deficit, may make an imp ortant contribution to cognitive decline in dementia of the Alzheimer type.