Td. Nelson et al., Rhodium-carbenoid-mediated intermolecular O-H insertion reactions: a dramatic additive effect. Application in the synthesis of an ascomycin derivative, TETRAHEDR L, 41(12), 2000, pp. 1877-1881
A catalyst system of Rh-2(oct)(4)/DIPEA or TMU allows for the rapid constru
ction of alpha-alkoxyketones from the corresponding alpha-diazo ketone and
alcohol. This methodology was applied to the synthesis of immunoregulant 1.
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