Rhodium-carbenoid-mediated intermolecular O-H insertion reactions: a dramatic additive effect. Application in the synthesis of an ascomycin derivative

Citation
Td. Nelson et al., Rhodium-carbenoid-mediated intermolecular O-H insertion reactions: a dramatic additive effect. Application in the synthesis of an ascomycin derivative, TETRAHEDR L, 41(12), 2000, pp. 1877-1881
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
0040-4039 → ACNP
Volume
41
Issue
12
Year of publication
2000
Pages
1877 - 1881
Database
ISI
SICI code
0040-4039(20000318)41:12<1877:RIOIRA>2.0.ZU;2-E
Abstract
A catalyst system of Rh-2(oct)(4)/DIPEA or TMU allows for the rapid constru ction of alpha-alkoxyketones from the corresponding alpha-diazo ketone and alcohol. This methodology was applied to the synthesis of immunoregulant 1. (C) 2000 Elsevier Science Ltd. All rights reserved.