Protective role of extracellular superoxide dismutase in hemodialysis patients

Citation
H. Yamada et al., Protective role of extracellular superoxide dismutase in hemodialysis patients, NEPHRON, 84(3), 2000, pp. 218-223
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
NEPHRON
ISSN journal
0028-2766 → ACNP
Volume
84
Issue
3
Year of publication
2000
Pages
218 - 223
Database
ISI
SICI code
0028-2766(200003)84:3<218:PROESD>2.0.ZU;2-4
Abstract
Background: The superoxide anion and other oxygen radicals have been implic ated in the progression of chronic renal failure, and are removed by extrac ellular superoxide dismutase (EC-SOD) in the extracellular space on the sur face of the endothelium. A single-base substitution of the EC-SOD gene whic h reduces the binding capability to endothelial cells resulting in an incre ased serum concentration, has been identified in healthy persons and hemodi alysis patients. Results: The proportion of patients with this mutation amo ng hemodialysis patients in each 20 months' duration after the initiation o f hemodialysis was retrospectively studied. The percentage of substitution- positive patients declined 80 months after the start of hemodialysis in non -DM patients. In contrast, in DM patients, the rapid decrease was obvious a s early as 40 months after the initiation of hemodialysis. By prospective s tudy for 5 years, there were significant differences in the survival rate b etween patients with and without R213G in DM, but not in non-DM patients. A mong those who died, the incidence of ischemic heart disease and cerebrovas cular disease in cases with R213G was significantly higher than in cases wi thout R213G. Conclusion: These results suggest that the presence of a subst itution in the EC-SOD gene at the heparin-binding domain could be a prognos tic marker of dialysis patients. Copyright (C) 2000 S. Karger AG, Basel.