Comparison of CT scan and MRI findings in the diagnosis of Japanese encephalitis

Citation
J. Kalita et Uk. Misra, Comparison of CT scan and MRI findings in the diagnosis of Japanese encephalitis, J NEUR SCI, 174(1), 2000, pp. 3-8
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN journal
0022-510X → ACNP
Volume
174
Issue
1
Year of publication
2000
Pages
3 - 8
Database
ISI
SICI code
0022-510X(20000301)174:1<3:COCSAM>2.0.ZU;2-Q
Abstract
Japanese encephalitis (JE) is the commonest endemic encephalitis but there are very few studies on the radiological changes and these are based on rel atively small number of patients. The present study aims at comparing the C T scan and MRI findings in JE and correlate these with the reported histopa thological findings. Forty two patients with JE were subjected to detailed neurological examination. Cranial CT scan was carried out in 38 and MRI sca n in 31 patients. Haemagglutination inhibition test was carried out in the acute and convalescent sera. The CT scan and MRI findings have been compare d. Both CT scan and MRI were available in 28 patients. In 21 patients, CT s cans were abnormal and changes included thalamic hypodensity in 15, midbrai n and basal ganglia hypodensity in 1 patient each, cerebral oedema in 4 and cortical atrophy with ventricular dilatation in 2 patients. MRI however wa s abnormal in all 31 patients including 17 with normal CT scan. Cranial MRI revealed either mixed intensity or hypointense lesion on T-1 and hyperinte nse or mixed intensity lesion on T-2 in thalami in all except two patients. The MRI lesions were also noted in basal ganglia in 11, midbrain in 18, pe ns in 8, cerebellum and cerebral cortex in 6 patients each and subcortical white matter in 2 patients. MRI was more sensitive than CT scan in revealin g thalamic and extrathalamic abnormalities. Thalamic changes may be helpful in the diagnosis of JE especially in endemic area. (C) 2000 Elsevier Scien ce B.V. All rights reserved.