Preprimed artificial lung for emergency use

Citation
E. Tatsumi et al., Preprimed artificial lung for emergency use, ARTIF ORGAN, 24(2), 2000, pp. 108-113
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
ARTIFICIAL ORGANS
ISSN journal
0160-564X → ACNP
Volume
24
Issue
2
Year of publication
2000
Pages
108 - 113
Database
ISI
SICI code
0160-564X(200002)24:2<108:PALFEU>2.0.ZU;2-W
Abstract
We investigated the possibility of preprimed storage of an artificial lung (AL), aiming at facilitating its emergency use. Test ALs, consisting of a s pecial microporous hollow fiber membrane made of polyolefin in which direct blood-gas contact was completely eliminated, were preprimed with saline so lution, sterilized by gamma-ray irradiation, and evaluated after 1-3 months of storage at room temperature. A small amount of bubble was noted in the priming solution after storage in some ALs, which most likely originated fr om the air dissolved in the priming solution or persisted in the liquid com partment at priming. Although the preprimed solution contained several poly olefin-breakdown products due to irradiation, including ethyl alcohol, n- a nd t-butyl alcohol, acetone, and carbon dioxide, the levels of these substa nces were at concentrations known to be not toxic. Endotoxin concentration was negligible. In SEM observation, no perceptible microstructural change w as observed in the hollow fibers after preprimed storage. Maximum tensile s tress and ultimate elongation of the hollow fiber in the test ALs were redu ced by approximately 20% and 3%, respectively, from those of the control AL . The influence of preprimed storage on gas-exchange function was examined in a venoarterial by-pass animal study using a goat. Oxygen transfer functi on was well preserved whereas carbon dioxide removal function was slightly lowered according to the storage term in the stored ALs compared with those of a nonpreprimed control AL. On the basis of these results, we conclude t hat preprimed storage of the AL with gamma-ray sterilization is basically f easible and realistic.