Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci

Citation
Db. Hoellman et al., Antipneumococcal activities of GAR-936 (a new glycylcycline) compared to those of nine other agents against penicillin-susceptible and -resistant pneumococci, ANTIM AG CH, 44(4), 2000, pp. 1085-1088
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
0066-4804 → ACNP
Volume
44
Issue
4
Year of publication
2000
Pages
1085 - 1088
Database
ISI
SICI code
0066-4804(200004)44:4<1085:AAOG(N>2.0.ZU;2-8
Abstract
GAR-936, a nem glycylcycline, had lo,ver MICs (less than or equal to 0.016 to 0.125 mu g/ml) for 201 peniciliin- and tetracycline-susceptible and -res istant pneumococcal strains than tetracycline (less than or equal to 0.06 t o 128 mu g/ml), minocycline (less than or equal to 0.06 to 16.0 mu g/ml), o r doxycycline (less than or equal to 0.06 to 32.0 mu g/ml). GAR-936 was als o bactericidal against 11 of 12 strains tested at the MIC after 24 h, with significant kill rates at earlier time points.