Haemostatic factors in human peripheral afferent lymph

Citation
Gj. Miller et al., Haemostatic factors in human peripheral afferent lymph, THROMB HAEM, 83(3), 2000, pp. 427-432
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS AND HAEMOSTASIS
ISSN journal
0340-6245 → ACNP
Volume
83
Issue
3
Year of publication
2000
Pages
427 - 432
Database
ISI
SICI code
0340-6245(200003)83:3<427:HFIHPA>2.0.ZU;2-U
Abstract
Peripheral afferent lymph was obtained by cannulation of a collecting vesse l in 17 healthy men (mean age 26 years). Lymph/plasma ratios of all vitamin K-dependent factors were lower than expected from molecular weight. Factor VII, factor IX and tissue factor pathway inhibitor (TFPI) lymph/plasma act ivity ratios were higher than antigen ratios. Activated factor VII (FVIIa) and TFPI-Xa complex concentrations were higher in lymph than plasma, and th e raised FVIIa did not appear to be due to cannulation. The fibrinogen lymp h/plasma activity (Clauss) ratio averaged about 20% of the antigen ratio. T he result of an ELISA for D-dimer was higher in lymph than plasma, often mo re than five-fold. This high level in lymph was not explored but may indica te proteolysis of fibrinogen and fibrin with release of D-like and D-dimer- like fragments in interstitial fluid.