Prognostic variables for patients with stage III malignant melanoma

Citation
Ge. Messaris et al., Prognostic variables for patients with stage III malignant melanoma, EURO J SURG, 166(3), 2000, pp. 233-239
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
EUROPEAN JOURNAL OF SURGERY
ISSN journal
1102-4151 → ACNP
Volume
166
Issue
3
Year of publication
2000
Pages
233 - 239
Database
ISI
SICI code
1102-4151(200003)166:3<233:PVFPWS>2.0.ZU;2-4
Abstract
Objective: To evaluate the prognostic factors for patients with stage III m alignant melanoma and to identify patients at high risk of developing recur rent disease who may benefit from adjuvant therapy. Design: Retrospective study. Setting: Specialist hospital, USA. Subjects: 130 patients with stage III malignant melanoma (according to the TNM classification), treated at the Roswell Park Cancer Institute between 1 970 and 1992. Main outcome measures: Survival and prognostic factors on multivariate anal ysis. Results: Four factors were independent prognostic indicators for patients w ith stage III malignant melanoma: age >51 years (p = 0.008), >3 involved ly mph nodes, (p = 0.03), the site of the primary tumour on head or trunk, (p = 0.007), and the presence of palpable lymph nodes (p = 0.004). Conclusion: These prognostic factors help us to stratify patients into low and high-risk groups. High-risk patients may benefit from more aggressive a djuvant therapy in future trials of treatment of melanoma.