Cell-substrate interactions and signaling through ILK

Authors
Citation
S. Dedhar, Cell-substrate interactions and signaling through ILK, CURR OP CEL, 12(2), 2000, pp. 250-256
Citations number
56
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
0955-0674 → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
250 - 256
Database
ISI
SICI code
0955-0674(200004)12:2<250:CIASTI>2.0.ZU;2-2
Abstract
Interactions between cells and the extracellular matrix (ECM) result in the regulation of cell growth, cell differentiation and cell migration. These interactions are mediated by integrins and growth factor receptors and intr acellular effecters that couple these receptors to downstream components ar e key to the transduction of ECM signals. This review summarizes recent adv ances in our understanding of signal transduction via integrins, focusing o n the role of integrin-linked kinase in some of these pathways. Research in to this interesting protein is uncovering novel aspects of coordinated sign aling by the ECM and growth factors.