A preliminary study on intravenous infusion of sodium eicosapentaenoate

Authors
Citation
Yj. Liu et D. Chen, A preliminary study on intravenous infusion of sodium eicosapentaenoate, DRUG DEV IN, 26(2), 2000, pp. 189-191
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
0363-9045 → ACNP
Volume
26
Issue
2
Year of publication
2000
Pages
189 - 191
Database
ISI
SICI code
0363-9045(2000)26:2<189:APSOII>2.0.ZU;2-N
Abstract
Eicosapentaenoic acid (EPA) and arachidonic acid (AA), made into sodium sal t solution (50 mu g/ml), were used for intravenous infusion. In a preclinic al study in dogs, Na-EPA lowered the activity of transminases (glutamic pyr uvic transaminase [GPT], glytamic oxaloacetic transaminase [GOT]); however, Na-AA increased the activity of GPT and GOT. In the clinical study, the nu mbers of leukocytes and lymphocytes of volunteers increased and remained at that level for 3 to 5 days after intravenous infusion. The study indicated that an intravenous infusion of Na-EPA may have anti-inflammatory and immu nomodulatory effects.