Corticobasal degeneration is a sporadic form of tauopathy, involving the ce
rebral cortex and extrapyramidal motor system. A series of affected subject
s was genotyped for a set of genetic markers along the tau protein gene. A
specific haplotype is significantly overrepresented in patients versus cont
rols. This haplotype is the same already reported in association with progr
essive supranuclear palsy. These data show that corticobasal degeneration a
nd progressive supranuclear palsy, in addition to several clinical, patholo
gical, and molecular features, may have the same genetic background.