Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy

Citation
E. Di Maria et al., Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy, ANN NEUROL, 47(3), 2000, pp. 374-377
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
0364-5134 → ACNP
Volume
47
Issue
3
Year of publication
2000
Pages
374 - 377
Database
ISI
SICI code
0364-5134(200003)47:3<374:CDSACG>2.0.ZU;2-1
Abstract
Corticobasal degeneration is a sporadic form of tauopathy, involving the ce rebral cortex and extrapyramidal motor system. A series of affected subject s was genotyped for a set of genetic markers along the tau protein gene. A specific haplotype is significantly overrepresented in patients versus cont rols. This haplotype is the same already reported in association with progr essive supranuclear palsy. These data show that corticobasal degeneration a nd progressive supranuclear palsy, in addition to several clinical, patholo gical, and molecular features, may have the same genetic background.