Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Citation
Je. Cox et al., Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions, AM J P-REG, 278(3), 2000, pp. R604-R610
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
ISSN journal
0363-6119 → ACNP
Volume
278
Issue
3
Year of publication
2000
Pages
R604 - R610
Database
ISI
SICI code
0363-6119(200003)278:3<R604:SOFIBW>2.0.ZU;2-Q
Abstract
Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumpti on of the liquid diet Boost, Mead Johnson, plus load) by similar to 15% and decreased weight gain compared with 4-day tests with saline administration . In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffec tive, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusi ons of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared w ith controls receiving saline. The net decrease in caloric intake may refle ct the combined activation of pre- and postabsorptive mechanisms, and it su ggests a possible treatment for obesity.