Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

Citation
L. Schio et al., Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B, TETRAHEDR L, 41(10), 2000, pp. 1543-1547
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
0040-4039 → ACNP
Volume
41
Issue
10
Year of publication
2000
Pages
1543 - 1547
Database
ISI
SICI code
0040-4039(20000304)41:10<1543:TIPCRA>2.0.ZU;2-R
Abstract
The palladium-catalysed coupling reaction between tosylate derivatives and organostannanes has been investigated as a methodology for carbon-carbon bo nd formation. Aryl substituents have been successfully incorporated even in highly functionalised coumarin structures to afford new analogues of the a ntibiotic novobiocin. (C) 2000 Elsevier Science Ltd. All rights reserved.