Transient receptor potential channels as molecular substrates of receptor-mediated cation entry

Citation
T. Hofmann et al., Transient receptor potential channels as molecular substrates of receptor-mediated cation entry, J MOL MED-J, 78(1), 2000, pp. 14-25
Citations number
113
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
JOURNAL OF MOLECULAR MEDICINE-JMM
ISSN journal
0946-2716 → ACNP
Volume
78
Issue
1
Year of publication
2000
Pages
14 - 25
Database
ISI
SICI code
0946-2716(2000)78:1<14:TRPCAM>2.0.ZU;2-X
Abstract
Calcium is a versatile multitarget intracellular second messenger in eukary otic cells. In addition to calcium release from intracellular stores and in flux via voltage- or ligand-operated channels, agonist-induced calcium entr y constitutes one of the main pathways by which cytosolic calcium is elevat ed. Receptor-stimulated currents are initiated in response to agonist bindi ng to G-protein-coupled receptors and to receptor tyrosine kinases. Within the past few years our knowledge about the molecular identity of receptor-s timulated channels has expanded substantially. Drosophila melanogaster visu al transduction channels associated with the transient receptor potential ( trp) and the trp-like (trpl) mutant visual phenotypes were the first member s of this category of channels to be identified at the molecular level. Sin ce then an entire mammalian gene family of TRP homologues has been discover ed by homology cloning. Only now are we beginning to fully understand the f unctional rates of TRP channels in mammalian cells. We review recent findin gs in TRP channel research and discuss the role of these proteins for recep tor-activated cation entry.