Tolerability and efficacy of intravenous administration of pantoprazole inroutine clinical practice

Citation
H. Bosseckert et al., Tolerability and efficacy of intravenous administration of pantoprazole inroutine clinical practice, CLIN DRUG I, 19(2), 2000, pp. 103-109
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
CLINICAL DRUG INVESTIGATION
ISSN journal
1173-2563 → ACNP
Volume
19
Issue
2
Year of publication
2000
Pages
103 - 109
Database
ISI
SICI code
1173-2563(200002)19:2<103:TAEOIA>2.0.ZU;2-G
Abstract
Objective: The efficacy of the proton pump inhibitor pantoprazole in the tr eatment of several acid-related diseases has been demonstrated in a number of clinical trials. The objective of this observational study was to observ e the tolerability and efficacy of intravenous pantoprazole in routine clin ical practice. Design and Setting: Observational multicentre study conducted in inpatients of 17 German university and community-based hospitals. Study Participants: 269 patients over the age of 18 years with gastric or d uodenal ulcer, reflux oesophagitis or other gastroduodenal disease were inc luded in the study. 214 patients (80%) suffered from a concomitant disease. Intervention: Patients were treated with intravenous pantoprazole. Main Outcome Measures and Results: Efficacy of the drug was good. In 241 pa tients (92%), treatment led to an improvement of the disease. The confidenc e interval of the relative frequency of treatment success was 91.9 to 92.1% . The multimorbidity rate of the study population was high and most patient s received concomitant medication. Nevertheless, tolerability of the drug w as assessed to be 'very good' or 'good' in 263 patients. Two 'unwanted drug reactions' occurred, but their relation to the intake of the study medicat ion was judged to be 'unlikely'. Conclusion: Intravenous pantoprazole is a well tolerated and effective drug for the routine clinical treatment of acid-related diseases in patients wi th a number of concomitant diseases.