The United Kingdom Childhood Cancer Study: objectives, materials and methods

Authors
Boulton, A Boyd, P Cheng, KK Cook, J Gilman, EA Lunt, D Mahler, H Walker, C Wardroper, M Darbyshire, PJ Hill, FGH Mann, JR Morland, B Raafat, F Stevens, MCG Ahmed, A Amos, P Bone, V Bonney, S Bray, M Cambouropoulos, P Cook, S Day, N Elkins, S Hensel, F Lucas, P Pettinger, J Pugsley, M Ruja, E Skinner, J Williams, D Braodbent, V Williams, M Alcock, M Bell, K Buchan, M Cartwright, R Cusack, H Fear, N Griffiths, S Jarvis, J Johnson, P Kane, E Law, G Moorman, A Prajapati, J Roberts, P Roman, E Simpson, J Sinclair, V Staines, A Thackrah, C Thistlethwaite, S Waller, B Bailey, C Kinsey, S Lewis, I Picton, S Squire, R Taylor, R Beck, JM Doran, RML Livingston, JH Van Hille, P Beddis, I Cameron, MM Craft, A Hale, J Kernahan, J Reid, M Windebank, K Pearson, A Skinner, R Marks, S Achilles, J Alam, S Birch, JM Blair, V Buckley, B Clarkson, M Eden, OB Howell, S Kellaway, C Lashford, L Leeke, S Leggett, P Murphy, AV O'Rorke, C Panton, S Paxon, J Pots, H Roberts, C Rothwell, J Stephenson, W Whelpton, B Caswell, M McDowell, H Pizer, BL Gattamaneri, R Brock, J Kelsey, AM Stevens, R Will, A Brennan, B Brydon, J Dodds, C Findlay, E Finucane, J Fraser, J Harkness, E Heary, A Hunter, N Juszczak, E Lang, M Lapsley, E McArthur, A MacCalman, A McKinney, PA Proudfoot, K Smith, C Smith, K Stockton, D Thomson, CS Vickers, R Wilkie, R King, D Mackinlay, G Shaw, P Thomas, A Wallace, H Carachi, R Gibson, BS Simpson, E Cruickshank, G Hide, TAH Gregor, A Steers, AJW Barrett, A Hamblen, DL Kaye, SB Mackie, R Allen, A Jones, AA Beeby, S Bignall, V Breeze, L Deacon, J MacDonald, M Matthews, F Meggitt, C Peto, J Sharpe, E Spencer, C Swales, J Thorne, M Trowbridge, P Webster-King, J Williams, E Bell, BA Johnston, FG Marsh, HT Uttley, D Bartlett, J Evans, A Gullan, RW Glaser, MG Peterson, D Southcott, BM Cavanagh, N Pearl, K Scott, D Darby, CW Chessels, J Evans, J Gaze, M Hann, IM Harkness, W Hayward, R Michalski, A Passmore, J Phillips, M Pritchard, J Clark, KGA MacDonald, EA Neville, BGR Robb, SA Robinson, RO Hardwidge, C Padgham, N Lobo, VJ Keen, C Hindmarsh, PC Kilby, AM Souhami, RL Tuft, S Thomas, RM Ward, P Scott, M Hoffbrand, AV Prentice, HG Gutteridge, CG Newland, AC Brada, M Henk, JM Meller, S Pinkerton, R Jones, KP Cannon, S Murrell, DS Hungerford, JL Kingston, JE Plowman, PN Young, B Ball, SE Capps, SNJ Davies, EG Holmes, SJK Carr, R Mercer, DM Smith, MA Andrews, VE Hughes, RG Ansell, P Baker, K Beral, V Black, J Boon, S Burge, C Burge, F Cliff, A Deciaccio, D Dorman, P Heydon, F Langley, N Pelerin, M Roemmele, J Sayers, K Townshend, P Harman, S Loftus, J Roth, S Lee, B Buchdahl, R Dunger, DB Mitchell, C Moncrieff, MKM Tam, PKH Wheeler, K Reiser, J Joss, V Moir, DJ Darmady, J Daish, P Liberman, MM Al-Izzi, MS Adams, CBT Kerr, RSC Teddy, PJ Barton, CJ Newman, CL Gabriel, CM O'Hea, M Sherrin, S Watson, A Douek, E Connell, JA Kelly, S Beswick, A Eldridge, B Elwood, P Hughes, J Phillips, M Webb, D Alexander, FE Bennett-Lloyd, B Davis, A Dunn, R Little, J Longdon, S Mitchell, M Muir, S Sturitis, J Kennedy, C Kohler, J Lang, D Radford, M Foreman, N Foot, A Mott, M Noblett, H Oakhill, A Sandeman, D Baumer, J Ward, P McNinch, A Gilbertson, N Bosley, A Richardson, S Challacombe, D French, T Bate, L Chilvers, CED Faulkner, G Hawtin, P Jenkinson, C Kelham, P Mackie, I Mackie, M Muir, KR O'Dwyer, J Williams, A Nelson, C Howarth, C Madi, M Shannon, R Forman, K Hewitt, M Punt, J Walker, D Gerrard, M Lilleyman, JS Vora, A Draper, G Harrison, C Doll, R Richards, S Ayres, M Carter, R Dearden, SP Hussain, A Kennedy, J Ravetto, P Ruprai, A Taylor, GM Taylor, J Watson, PD Colman, SM Greaves, MF Price, CM Goodhead, DT Allen, S Bartlett, D Blackwell, RP Fry, F Maslanyj, M Mee, T Miles, J Adams, G
Citation
A. Boulton et al., The United Kingdom Childhood Cancer Study: objectives, materials and methods, BR J CANC, 82(5), 2000, pp. 1073-1102
Citations number
110
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
0007-0920 → ACNP
Volume
82
Issue
5
Year of publication
2000
Pages
1073 - 1102
Database
ISI
SICI code
0007-0920(200003)82:5<1073:TUKCCS>2.0.ZU;2-O
Abstract
An investigation into the possible causes of childhood cancer has been carr ied out throughout England, Scotland and Wales over the period 1991-1998. A ll children known to be suffering from one or other type of the disease ove r periods of 4-5 years have been included, and control children matched for sex, age and area of residence have been selected at random from populatio n registers. Information about both groups of children (with and without ca ncer) has been obtained from parental questionnaires, general practitioners ' and hospital records, and from measurement of the extent of exposure to r adon gas, terrestrial gamma radiation, and electric and magnetic fields. Sa mples of blood have also been obtained from the affected children and their parents and stored. Altogether 3838 children with cancer, including 1736 w ith leukaemia, and 7629 unaffected children have been studied. Detailed acc ounts are given of the nature of the information obtained in sections descr ibing the general methodology of the study, the measurement of exposure to ionizing and non-ionizing radiation, the classification of solid rumours an d leukaemias, and the biological material available for genetic analysis. ( C) 2000 Cancer Research Campaign.