Objective: To review the experience of women who conceived after developing
mastocytosis and who were observed at the National Institutes of Health.
Methods: We reviewed our patient database for the years 1984-1998 to identi
fy women with mastocytosis who had conceived. We then reviewed each woman's
record, asked each woman to complete a questionnaire, and with permission
wrote outside hospitals to obtain records of each labor and delivery.
Results: We identified eight women who had become pregnant. These women del
ivered a total of 11 live infants. In approximately a third of the pregnanc
ies, patients experienced:worsening of symptoms. They often used fewer medi
cations during pregnancy because of safety concerns, and no greater inciden
ce of adverse reactions was noted. Antihistamines were used most commonly,
followed by oral prednisone. Medications used during delivery were well tol
erated and included epidural analgesics. Neonates were generally healthy. N
one ito date have developed urticaria pigmentosa or systemic mastocytosis.
Conclusion: A subset of women with mastocytosis might have had exacerbated
mastocytosis during and after pregnancy, but labor and delivery progressed
normally. Infants were born generally healthy and were without mastocytosis
. Thus there appears to be no absolute contraindication to pregnancy for wo
men with mastocytosis, although women should be aware that the choice to ha
ve a child is not without some added risk. (Obstet Gynecol 2000;95:391-5.).