Possible involvement of central C-type natriuretic polypeptide receptor onwater intake in spontaneously hypertensive rats, but not in normotensive Wistar-Kyoto rats

Citation
K. Shibata et al., Possible involvement of central C-type natriuretic polypeptide receptor onwater intake in spontaneously hypertensive rats, but not in normotensive Wistar-Kyoto rats, NEUROPEPTID, 33(6), 1999, pp. 503-509
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPEPTIDES
ISSN journal
0143-4179 → ACNP
Volume
33
Issue
6
Year of publication
1999
Pages
503 - 509
Database
ISI
SICI code
0143-4179(199912)33:6<503:PIOCCN>2.0.ZU;2-M
Abstract
The present study was designed to examine the possible role of brain C-type natriuretic polypeptide receptor (GC-B) in spontaneously hypertensive (SHR ) and normotensive Wistar-Kyoto rats (WKY). The level of GC-B mRNA in vario us regions of the brain in both SHR and WKY was examined in the present stu dy. The GC-B mRNA was unevenly distributed in rat brain, the transcript bei ng expressed predominantly in the hypothalamus and cerebellum but comparati vely at low level in the striatum and septum. However, the level in the sep tum was 3-fold higher in SHR than than in age-matched WKY, while no differe nces were observed in other regions of the brain. Intracerebroventricular a dministration of antisense oligonucleotide to GC-B mRNA inhibits the night- time water intake in SHR, but not in WKY. However, the daily food intake wa s not significantly altered by the injection of antisense oligonucleotide i n both strains. These results demonstrate that the brain GC-B mRNA, particularly in septum, is increased in SHR and this increase may be closely related to the regula tion of water-drinking behaviour in SHR. (C) 1999 Harcourt Publishers Ltd.