Measurement of protein C inhibitor in seminal plasma is useful for detecting agenesis of seminal vesicles or the vas deferens

Citation
H. Kise et al., Measurement of protein C inhibitor in seminal plasma is useful for detecting agenesis of seminal vesicles or the vas deferens, J ANDROLOGY, 21(2), 2000, pp. 207-212
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
JOURNAL OF ANDROLOGY
ISSN journal
0196-3635 → ACNP
Volume
21
Issue
2
Year of publication
2000
Pages
207 - 212
Database
ISI
SICI code
0196-3635(200003/04)21:2<207:MOPCII>2.0.ZU;2-P
Abstract
Protein C inhibitor (PCI), a plasma serine protease inhibitor of activated protein C, is present at high concentrations in the seminal plasma of norma l subjects and is decreased in some infertile patients. We measured the con centrations of PCI, prostate-specific antigen, and fructose in the seminar plasma of infertile patients (n = 125) and of normal subjects (n = 13). We also measured time-dependent changes in the concentrations of PCI and fruct ose in seminal plasma after ejaculation. A weak correlation was found betwe en the levels of PCI and fructose (r = 0.268, P = 0.016). The PCI level in seminal plasma of patients with seminal vesicle and/or vasal agenesis was s ignificantly lower (P < .01) than in normal subjects. The level of fructose in seminal plasma decreased in vitro in a time-dependent manner after ejac ulation, whereas the concentration of PCI was stable at 48 hours after ejac ulation. These data suggest that PCI in seminal plasma, as well as fructose , may become one of the markers for agenesis of seminal vesicles and/or the vas deferens.