BCL6 REARRANGEMENT IN A PATIENT WITH MANTLE CELL LYMPHOMA

Citation
I. Miura et al., BCL6 REARRANGEMENT IN A PATIENT WITH MANTLE CELL LYMPHOMA, Annals of hematology, 74(5), 1997, pp. 247-250
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
ISSN journal
0939-5555
Volume
74
Issue
5
Year of publication
1997
Pages
247 - 250
Database
ISI
SICI code
0939-5555(1997)74:5<247:BRIAPW>2.0.ZU;2-5
Abstract
We describe a patient with mantle cell lymphoma (MCL) associated with BCL6 gene rearrangement. MCL is a distinct subtype of non-Hodgkin's ly mphoma characterized by CD5+, CD10-, CD20+, t(11;14)(q13;q32) and PRAD 1/cyclin D1 overexpression. Although rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some fol licular lymphomas this is the first report of a patient with MCL assoc iated with BCL6 rearrangement.