Wheat bran and breast cancer. Revisiting the estrogen hypothesis.

Citation
Jp. Pena-rosas et al., Wheat bran and breast cancer. Revisiting the estrogen hypothesis., ARCH LAT NU, 49(4), 1999, pp. 309-317
Citations number
69
Language
SPAGNOLO
art.tipo
Article
Categorie Soggetti
Food Science/Nutrition
Journal title
ARCHIVOS LATINOAMERICANOS DE NUTRICION
ISSN journal
0004-0622 → ACNP
Volume
49
Issue
4
Year of publication
1999
Pages
309 - 317
Database
ISI
SICI code
0004-0622(199912)49:4<309:WBABCR>2.0.ZU;2-Q
Abstract
Breast cancer is the most relevant form of cancer among women in Latin Amer ica. Many studies have evaluated the hormonal mechanisms involved in mammar y carcinogenesis, although new focus is aimed towards factors that can pote ntially be used individually to reduce risk. Wheat bran seems to show a con sistent protective effect in mammary carcinogenesis. Wheat bran, besides hi gh level of insoluble fiber, also contains phytic acid and lignins, phytoch emicals that have shown to inhibit in vitro and in vivo growth of mammary c ancer. The protective effect of wheat bran in breast carcinogenesis is grea test at the promotional phase and when supplemented to a high fat diet. Dos es of wheat bran in the 9-12% range have been consistently protective and t he inconsistencies observed at higher doses may be dependent on the animal model used. This review examines the protective role of wheat bran in the d evelopment of breast cancer and the possible mechanisms involved.