Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension

Citation
Rj. Stratton et al., Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension, ANN RHEUM D, 59(2), 2000, pp. 132-134
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Rheumatology,"da verificare
Journal title
ANNALS OF THE RHEUMATIC DISEASES
ISSN journal
0003-4967 → ACNP
Volume
59
Issue
2
Year of publication
2000
Pages
132 - 134
Database
ISI
SICI code
0003-4967(200002)59:2<132:STCIRI>2.0.ZU;2-Z
Abstract
Objective-To investigate the expression of thrombomodulin in scleroderma as sociated pulmonary hypertension. Methods-Soluble thrombomodulin (sTM), was measured in plasma samples from 3 4 scleroderma patients shown to have pulmonary hypertension at echocardiogr am, and comparison drawn against samples from 38 scleroderma control patien ts, acid 20 healthy controls. Serial measurements of sTM were performed in the 34 patients with scleroderma associated pulmonary hypertension to inves tigate possible changes in sTM concentration with progression of the condit ion. Results-Mean sTM was raised in scleroderma associated pulmonary hypertensio n when compared with scleroderma controls (mean sTM 65.4 ng/ml v 43.3 ng/ml , p<0.05), and when compared with healthy controls (mean sTM 38.1 ng/ml, p< 0.05). There was no significant difference between mean sTIM in scleroderma controls and healthy controls. Mean sTM concentration did not change with progression of pulmonary hypertension. Conclusion-Plasma sTM is raised in scleroderma associated pulmonary hyperte nsion. The pathogenesis of scleroderma associated pulmonary hypertension ma y be distinct from the pathogenesis of other forms of pulmonary vascular di sease.