Chemiluminescence determination of thioridazine hydrochloride by flow-injection analysis

Citation
A. Kojlo et al., Chemiluminescence determination of thioridazine hydrochloride by flow-injection analysis, J PHARM B, 22(1), 2000, pp. 85-91
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
0731-7085 → ACNP
Volume
22
Issue
1
Year of publication
2000
Pages
85 - 91
Database
ISI
SICI code
0731-7085(200002)22:1<85:CDOTHB>2.0.ZU;2-F
Abstract
Hydrogen peroxide, potassium permanganate, potassium dichromate. potassium hexacyanoferrate(III), cerium(IV) sulphate and sodium peroxidisulphate have been tested as potential reagents for chemiluminescence generation from th e oxidation of phenothiazine derivatives. Only with potassium permanganale in acidic medium were satisfying results achieved, A total of 13 different phenothiazine derivatives produce luminescence of different intensities on oxidation. Thioridazine hydrochloride was chosen to develop,a rapid and sim ple method for its determination in pharmaceutical formulations. The limit of detection is 1.2 x 10(-6) mol l(-1), and 110 samples per hour can be det ermined. (C) 2000 Elsevier Science B.V. All rights reserved.