Effects of metoprolol and ramipril on action potentials after myocardial infarction in rats

Citation
Kd. Wagner et al., Effects of metoprolol and ramipril on action potentials after myocardial infarction in rats, EUR J PHARM, 388(3), 2000, pp. 263-266
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
0014-2999 → ACNP
Volume
388
Issue
3
Year of publication
2000
Pages
263 - 266
Database
ISI
SICI code
0014-2999(20000204)388:3<263:EOMARO>2.0.ZU;2-I
Abstract
The effects of chronic treatment with the beta-adrenoceptor antagonist meto prolol, the angiotensin converting enzyme inhibitor ramipril, their combina tion, or placebo on action potential configuration 6 weeks after myocardial infarction in rats were studied. Action potentials were measured in isolat ed left ventricular posterior papillary muscles and compared with action po tentials from a sham operated group without infarction. After infarction, t he action potential amplitude was reduced and this phenomenon was partially reversed by metoprolol- and ramipril-treatment. Prolonged repolarisation a fter infarction compared to sham operated animals was additionally delayed after metoprolol treatment. Thus, metoprolol extends the refractory period, which may counteract tachyarrhythmia. (C) 2000 Elsevier Science B.V. All r ights reserved.