1. The effects of soluble dietary fibre (psyllium) on peripheral insulin se
nsitivity and skeletal muscle GLUT-4 protein expression were studied in 12
male stroke-prone spontaneously hypertensive rats (SHRSP) fed a high-calori
c diet from 5 to 9 weeks of age.
2. In the psyllium-supplemented group, fasting plasma glucose was significa
ntly reduced and glucose levels following an oral glucose tolerance test we
re significantly lower than in the cellulose-supplemented group at 30 (P <
0.05) and 60 min (P < 0.01). However, there was no difference in insulin se
3, In the psyllium-supplemented group skeletal muscle LUT-4 content was sig
nificantly increased in the plasma membrane (P < 0.001), but not in the int
4. No significant difference was found in phosphatidylinositol 3 (PI3)-kina
se activity between cellulose and psyllium diet not only in the basal state
but also when stimulated by insulin.
5. These results demonstrate that psyllium increases blood glucose disposal
by increasing skeletal muscle plasma membrane GLUT-4 content without PI3-k