fThe stereoselective synthesis of 5-monosubstituted and 5,5-dialkylsubstitu
ted noviose derivatives has been achieved starting from L-arabinose. These
noviose derivatives could be used as useful building blocks in probing stru
cture-activity relationships (SAR) of coumarin antibiotics that are inhibit
ors of DNA gyrase. (C) 2000 Elsevier Science Ltd. All rights reserved.