The potential role of gene therapy in the treatment of bladder cancer

Citation
Jt. Hsieh et al., The potential role of gene therapy in the treatment of bladder cancer, UROL CLIN N, 27(1), 2000, pp. 103
Citations number
83
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
Journal title
UROLOGIC CLINICS OF NORTH AMERICA
ISSN journal
0094-0143 → ACNP
Volume
27
Issue
1
Year of publication
2000
Database
ISI
SICI code
0094-0143(200002)27:1<103:TPROGT>2.0.ZU;2-T
Abstract
Based on understanding the molecular mechanism of bladder carcinogenesis, c ancer gene therapy may well become a novel therapy in the near future. Curr ently, a viral vector system appears to be a better vehicle to deliver gene s into target cells. Exploring different therapeutic strategies has generat ed promising results from preclinical bladder cancer models. Phase I clinic al trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated wi th effective gene delivery need to be further refined.