Cytokine and hormonal responses in laparoscopic-assisted colectomy and conventional open colectomy

Citation
A. Ozawa et al., Cytokine and hormonal responses in laparoscopic-assisted colectomy and conventional open colectomy, SURG TODAY, 30(2), 2000, pp. 107-111
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
ISSN journal
0941-1291 → ACNP
Volume
30
Issue
2
Year of publication
2000
Pages
107 - 111
Database
ISI
SICI code
0941-1291(2000)30:2<107:CAHRIL>2.0.ZU;2-F
Abstract
Interleukin-6 (IL-6) is an important mediator of the acute phase response a nd a sensitive marker of tissue damage. This study was conducted to investi gate the fluctuation of serum cytokine and hormonal levels during the perio perative period after laparoscopic-assisted colectomy (LAC), and the data w ere compared with those after conventional open colectomy (OPEN). The subje cts comprised eight patients who underwent OPEN and eight who underwent LAG . Blood samples were obtained by peripheral vein puncture before the induct ion of anesthesia, then 2, 4, 6, 8, 24, 48, and 72 h after skin incision to measure the levels of serum IL-6, adrenocorticotropic hormone (ACTH), cort isol, and antidiuretic hormone (ADH). The level of serum IL-6 increased sig nificantly during the perioperative course in both groups; however, the lev el 4 h after the commencement of surgery and the peak level were significan tly lower in the LAC group than in the OPEN group (P < 0.05). Plasma ACTH, cortisol, and ADH rapidly increased in both groups, but there was no signif icant difference between them, The IL-6 levels in collected ascites samples were not significantly different between the two groups. The changes in se rum IL-6 levels indicate that LAC is less invasive than conventional open c olectomy. These findings corresponded well with the clinical courses of the patients who underwent the two types of operations.