Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies

Citation
K. Iwasa et al., Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies, NEUROLOGY, 54(3), 2000, pp. 757-759
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
0028-3878 → ACNP
Volume
54
Issue
3
Year of publication
2000
Pages
757 - 759
Database
ISI
SICI code
0028-3878(20000208)54:3<757:RCCIRB>2.0.ZU;2-H
Abstract
The authors studied sera from 36 patients with Lambert-Eaton myasthenic syn drome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type volta ge-gated calcium channel alpha 1 subunit. The results of 18 patients were p ositive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.