Maternal bone lead contribution to blood lead during and after pregnancy

Citation
Sj. Rothenberg et al., Maternal bone lead contribution to blood lead during and after pregnancy, ENVIR RES, 82(1), 2000, pp. 81-90
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Environment/Ecology,"Pharmacology & Toxicology
Journal title
ENVIRONMENTAL RESEARCH
ISSN journal
0013-9351 → ACNP
Volume
82
Issue
1
Year of publication
2000
Pages
81 - 90
Database
ISI
SICI code
0013-9351(200001)82:1<81:MBLCTB>2.0.ZU;2-U
Abstract
We examined bone lead contribution to blood lead in a group of 311 immigran t women, 99% from Latin America, during the third trimester of pregnancy an d 1 to 2 months after delivery. We measured in vivo tibia and calcaneus (he el) bone lead concentration in the postdelivery period with K shell X-ray f luorescence. Prenatal and postnatal geometric mean (range) blood lead level was 2.2 mu g/dL (0.4 to 38.7) and 2.8 mu g/dL (0.4 to 25.4), reflecting lo w current exposure. Postnatal blood lead level was significantly higher tha n prenatal (P < 0.0001). Mean (range) tibia and calcaneus lead concentratio n was 6.7 mu g/g (-33.7 to 62.2) and 8.4 mu g/g (-30.1 to 66.4), reflecting varying but elevated past lead exposure. Mean calcaneus lead concentration was significantly higher than mean tibia lead concentration (P = 0.055). V ariance-weighted multiple regression and structural equation models showed that both calcaneus and tibia lead were directly associated with prenatal b lood lead but only calcaneus lead was associated with postnatal blood lead. Increasing natural log years in the United States independently predicted decreasing calcaneus and third-trimester blood lead. The data suggest that while some exogenous lead sources and modulators of blood lead level, such as use of lead-glazed pottery and calcium in the diet, control lead exposur e during and after pregnancy, endogenous lead sources from past exposure be fore immigration continue to influence blood lead levels in this sample. (C ) 2000 Academic Press.