Concentrations of plasma methylmalonic acid in 80-year-olds show only weakrelation to psychological performance

Citation
B. Hultberg et al., Concentrations of plasma methylmalonic acid in 80-year-olds show only weakrelation to psychological performance, CLIN CH L M, 37(10), 1999, pp. 963-967
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
ISSN journal
1434-6621 → ACNP
Volume
37
Issue
10
Year of publication
1999
Pages
963 - 967
Database
ISI
SICI code
1434-6621(199910)37:10<963:COPMAI>2.0.ZU;2-2
Abstract
Most studies of the relation between psychological performance in the elder ly and deficiencies of cobalamin and folate have used methods that determin e the blood concentrations of these vitamins, which might not reflect the v itamin status in the tissues. Recently, two new markers, plasma homocystein e and methylmalonic acid, have attracted growing interest since they are co nsidered to reflect the status of cobalamins and folates in the tissues. In a previous study, we noted a strong association between five parameters of well-being and lower concentrations of plasma homocysteine. In the present study, we have extended these observations by determination of plasma meth ylmalonic acid in the same healthy elderly population. In the present study , 18 out of 100 subjects had increased plasma methylmalonic acid and in 7 o f these subjects, the concentrations of serum cobalamin, blood folate, plas ma homocysteine and serum creatinine were within normal limits. The relatio n between plasma methylmalonic acid concentrations and concentrations of se rum cobalamin and blood folates and five parameters of well-being were inve stigated. Concentrations of plasma methylmalonic acid were only weakly asso ciated with the concentrations of serum cobalamin and lower scores on the l ogical reasoning test. The present study clearly shows that the levels of p lasma methylmalonic acid show a much lesser association with the parameters of well-being than did plasma homocysteine.