Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure

Citation
Yh. Lee et al., Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure, INT J PHARM, 194(2), 2000, pp. 221-227
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
0378-5173 → ACNP
Volume
194
Issue
2
Year of publication
2000
Pages
221 - 227
Database
ISI
SICI code
0378-5173(20000125)194:2<221:PCOCAI>2.0.ZU;2-O
Abstract
The effects of renal failure on the pharmacokinetics of cyclosporine were i nvestigated after intravenous, 30 mg/kg, and oral, 100 mg/kg, administratio n of the drug using a rat model of uranyl nitrate-induced acute renal failu re (U-ARF). After intravenous administration to rats with U-ARF, the volume of distribution at steady state (1.97 vs. 2.56 1/kg) was significantly sma ller, and the area under the blood concentration-time curve (348 vs. 296 mu g h/ml) tended to be greater and total body clearance (0.0851 vs. 0.102 1/ h per kg) tended to be slower than those in control rats. After oral admini stration, the pharmacokinetic parameters were not significantly different b etween the control rats and rats with U-ARF, suggesting that U-ARF did not considerably affect the pharmacokinetics of cyclosporine after oral adminis tration. (C) 2000 Elsevier Science B.V. All rights reserved.