Bi-directional signal transduction by integrin receptors

Citation
Mg. Coppolino et S. Dedhar, Bi-directional signal transduction by integrin receptors, INT J BIO C, 32(2), 2000, pp. 171-188
Citations number
155
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Biochemistry & Biophysics
Journal title
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
ISSN journal
1357-2725 → ACNP
Volume
32
Issue
2
Year of publication
2000
Pages
171 - 188
Database
ISI
SICI code
1357-2725(200002)32:2<171:BSTBIR>2.0.ZU;2-1
Abstract
The integrin family of cell surface glycoproteins functions primarily as re ceptors for extracellular matrix ligands. There are now many well character ized integrin-ligand interactions which are known to influence many aspects of cell behaviour including cell morphology, cell adhesion, cell migration as well as cellular proliferation and differentiation. However, in fulfill ing these functions, integrins are not simple adhesion receptors that physi cally mediate connections across the plasma membrane. Rather, integrin func tion itself is highly regulated, largely through the formation of specific associations with both structural and regulatory components within cells. I t is these intracellular interactions which allow integrin function to effe ct many biochemical signalling pathways and therefore to impinge upon compl ex cellular activities. Recently, much research has focused on elucidating the molecular mechanisms which control integrin function and the molecular processes which transduce integrin-mediated signalling events. In this revi ew, we discuss progress in the field of integrin signal transduction includ ing, where applicable, potential therapeutic applications arising from the research. (C) 2000 Elsevier Science Ltd. All rights reserved.